Poxviruses, including the notorious smallpox, have shaped history with their deadly impact. Mpox, formerly known as monkeypox, gained global attention during a widespread outbreak from 2022-2023, underscoring its potential threat. Recent genomic studies shed light on its evolution and transmission dynamics, revealing genomic “accordions” that expand and contract, influencing virulence and adaptability. Clade IIb emerged as highly transmissible, raising concerns of endemicity. Subsequent outbreaks, like the one in the Democratic Republic of the Congo, highlight evolving virulence and transmission patterns, necessitating swift genomic surveillance and public health measures to curb future threats.
Unveiling the Intricacies of Mpox: A Tale of Evolution and Outbreaks
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