Scientists at HHMI’s Janelia Research Campus are adapting phase diversity techniques from astronomy to enhance microscopy for biological samples. Unlike traditional adaptive optics, phase diversity integrates known aberrations into images to correct distortions, improving clarity without major system modifications. They developed and validated this approach with simulations and a modified microscope featuring a deformable mirror and additional lenses. Initial tests demonstrated rapid calibration and correction of aberrations, yielding clearer images of fluorescent beads and cells.
Advancing Microscopy: Applying Astronomy Techniques for Clearer Biological Imaging
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