A recent study as part of the U.K.’s ‘100,000 Genome Program’ demonstrates the transformative potential of cancer genomics in cancer care. Whole-genome sequencing (WGS) revealed DNA changes in cancer patients that could guide treatment strategies, offering novel insights into various cancer types. The study aligns with the NHS’s vision for harnessing genomic medicine to enhance cancer care, emphasizing precision medicine’s promise. While groundbreaking, researchers emphasize the need for a nuanced perspective, considering the challenges and the evolving landscape of genomic-guided treatments in clinical care.